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2019年11月9日刘志军教授学术报告
上传时间:2019-11-04 作者: 浏览次数:11

报告题目:Complete dynamical analysis for a nonlinear HTLV-I infection model with distributed delay, CTL response and immune impairment

人:刘志军 教授

报告内容:It is well known that CTL (cytotoxic T lymphocyte) immune response could be broadly classified into lytic and nonlytic components, nonlinear functions can better reproduce saturated effects in the interaction processes between cell and viral populations, and distributed intracellular delay can realistically reflect the stochastic element in the delay effects. For these reasons, we develop an HTLV-I (Human T-cell leukemia virus type I) infection model with nonlinear lytic and nonlytic CTL immune responses, nonlinear incidence rate, distributed intracellular delay and immune impairment. Through conducting complete analysis, it is revealed that all these factors influence the concentration level of infected T-cells at the chronic-infection equilibrium, whereas intracellular distributed delay and nonlinear incidence rate may change the expression of the basic reproduction number R0 in the context where the model proposed still preserves the threshold dynamics. Our analysis results obtained may improve several existing works by comparison. We also perform global sensitivity analysis for R0 in order to explore the effective strategies of lowering the concentration level of infected T-cells.

 

报告人简介:刘志军,湖北民族大学理学院院长、博士、二级教授、硕士生导师、四川大学兼职博士生导师,中国生物数学学会、湖北省数学学会和湖北省工业与应用数学学会常务理事,美国《数学评论》评论员。主持在研国家自然科学基金面上项目1项,主持完成国家自然科学基金地区项目、教育部科学技术重点项目、中国博士后科学基金、湖北省自然科学基金各1项。以第一作者和通讯作者在SCI期刊上发表学术论文40余篇,获湖北省自然科学奖三等奖1项(排序第二)。

 

报告时间:2019119 16:00-17:00

报告地点:理学院学术报告厅(6教南楼528

 

 


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